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. 2013 Oct;398(7):997-1000.
doi: 10.1007/s00423-013-1084-3. Epub 2013 May 17.

Local tissue ischemia is not necessary for suture-induced adhesion formation

Taufiek Konrad Rajab  1 , Christoph Brochhausen, Markus Wallwiener
Affiliations

Local tissue ischemia is not necessary for suture-induced adhesion formation

Taufiek Konrad Rajab et al. Langenbecks Arch Surg. 2013 Oct.

Abstract

Background: We investigated the hypothesis that local tissue ischemia is responsible for suture-induced adhesion formation.

Methods: A total of 160 interrupted sutures were placed in the parietal peritoneum of 20 Wistar rats. The animals were randomized into an ischemia group, where the sutures were pulled tight and a non-ischemia group, where the sutures were tied as loose loops with air knots to avoid any local ischemia. The midline laparotomy was closed with a running suture. On postoperative day 10, adhesions to the sutures were counted.

Results: There was no statistically significant difference in the number of adhesions forming to sutures with local ischemia (n = 66/80) versus sutures without local ischemia (n = 69/80).

Conclusion: We conclude that local tissue ischemia is not necessary for suture-induced adhesion formation and propose an additional mechanical mechanism to explain how suture knots can predispose to adhesiogenesis.

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