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Review
. 2013 Jun;13(6):453-60.
doi: 10.1038/nri3446. Epub 2013 May 17.

The history of Toll-like receptors - redefining innate immunity

Luke A J O'Neill  1 , Douglas Golenbock, Andrew G Bowie
Affiliations
Review

The history of Toll-like receptors - redefining innate immunity

Luke A J O'Neill et al. Nat Rev Immunol. 2013 Jun.

Abstract

The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research.

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