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Review
. 2013 Aug;13(4):347-53.
doi: 10.1007/s11882-013-0352-1.

Celiac disease and autoimmunity: review and controversies

Jolanda M Denham  1 , Ivor D Hill
Affiliations
Review

Celiac disease and autoimmunity: review and controversies

Jolanda M Denham et al. Curr Allergy Asthma Rep. 2013 Aug.

Abstract

Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.

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Conflict of interest statement

Jolanda M. Denham declares that she has no conflict of interest.

Ivor D. Hill declares that he has no conflict of interest.

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