Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 May 15:2013:bcr2012008367.
doi: 10.1136/bcr-2012-008367.

Reninoma: a rare cause of curable hypertension

Ramanathan Venkateswaran  1 , Abdoul Hamide, Lalgudi Narayanan Dorairajan, Debdatta Basu
Affiliations
Case Reports

Reninoma: a rare cause of curable hypertension

Ramanathan Venkateswaran et al. BMJ Case Rep. .

Abstract

A 25-year-old lady presented with hypertensive encephalopathy. She also had chronic refractory hypertension for the past 7 years. Workup revealed persistent hypokalaemia with metabolic alkalosis suggesting hyperaldosteronism. Hyperaldosteronic states such as renal artery stenosis, Conn's syndrome and Liddle's syndrome were ruled out. Her plasma renin activity was high. Contrast-enhanced CT of the abdomen showed a 1.9×2 cm heterogeneously enhancing lesion in the anterior aspect of the right kidney suggesting a possibility of reninoma. The benign tumour was resected by a nephron-sparing surgery. Histopathology suggested a juxtaglomerular cell tumour. Anti-hypertensive drugs were completely withdrawn postoperatively.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Causes of hyperaldosteronism.
Figure 2
Figure 2
Contrast-enhanced CT  scan of the abdomen showing a heterogeneously enhancing mass in the anterior cortex of the right kidney (arrow).
Figure 3
Figure 3
(A) Cut section showing a well-circumscribed tumour with a soft fleshy pale pink appearance measuring 2 cm in the maximum dimension. (B) Islands of monomorphic tumour cells with vesicular nucleus, arranged in an organoid pattern (H&E ×400). (C) Tumour cells showing positivity for CD34 (IHC ×400).
See this image and copyright information in PMC

References

    1. Martin SA, Mynderse LA, Lager DJ, et al. Juxtaglomerular cell tumour: a clinicopathologic study of four cases and review of the literature. Am J Clin Pathol 2001;2013:854–63 - PubMed
    1. Robertson PW, Klidjian A, Harding LK, et al. Hypertension due to a renin-secreting renal tumour. Am J Med 1967;2013:963. - PubMed
    1. Wong L, Hsu THS, Perlroth MG, et al. Reninoma: a case report and literature review. J Hypertens 2008;2013:368–73 - PubMed
    1. Gottardo F, Cesari M, Morra A, et al. A kidney tumor in an adolescent with severe hypertension and hypokalemia: an uncommon case—case report and review of the literature on reninoma. Urol Int 2010;2013:121–4 - PubMed
    1. Helena AG, Amal FF. Evaluation of endocrine function. In McPherson RA, Pincus MR, eds. Henry's clinical diagnosis and management by laboratory methods. 22nd edn Philadelphia: WB Saunders Elsevier, 2011:397–400

Publication types