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Case Reports
. 2013 May 15:2013:bcr2013009550.
doi: 10.1136/bcr-2013-009550.

Aortic valve tethering: embryonic remnant of a common origin?

Luis Alvarez-Acosta  1 , Estanislao Soriano-Vela, Maria Facenda-Lorenzo, Marcos Farrais-Villalba
Affiliations
Case Reports

Aortic valve tethering: embryonic remnant of a common origin?

Luis Alvarez-Acosta et al. BMJ Case Rep. .

Abstract

A 14-year-old asymptomatic girl without relevant medical history was referred to our department for heart murmur evaluation. The echocardiogram showed cardiac chambers with normal size and function. Noteworthy was the presence of an apparently fibrous tissue joining the ventricular surfaces of the aortic non-coronary and right coronary leaflets with the anterior mitral leaflet. Both valves were slightly thickened and there was a mild anterior mitral valve 'billowing' causing an eccentric mild-to-moderate regurgitant jet. During systole, tethering of this tissue caused the incomplete opening of both mentioned aortic leaflets, causing a turbulent flow with no significant gradient across the valve. During diastole, moderate eccentric aortic regurgitation jet was noted, probably related to incomplete coaptation at the insertion point of this anomalous tissue. We speculate that this finding may represent the remnant of some tissue during heart development that abnormally persisted in this young lady.

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Figures

Figure 1
Figure 1
(A) Long axis view end-diastole. (B) Long axis view diastole. (C) Short axis view. (D) Colour flow diastole. String-like tissue (arrows).
See this image and copyright information in PMC

References

    1. Snarr B, Kern C, Wessels A. Origin and fate of cardiac mesenchyme. Dev dyn 2008;2013:2804–19 - PubMed
    1. Combs MD, Yutzey KE. Heart valve development: regulatory networks in development and disease. Circ Res 2009;2013:408–21 - PMC - PubMed
    1. Schoen FJ. Evolving concepts of cardiac valve dynamics. Circulation 2008;2013:1864–80 - PubMed
    1. Hinton RB, Lincoln J, Deutsch GH, et al. Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ Res 2006;2013:1431–8 - PubMed
    1. Moorman A, Webb S, Brown NA, et al. Development of the heart: formation of the cardiac chambers and arterial trunks. Heart 2003;2013:806–14 - PMC - PubMed

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