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. 2013 Feb;15(2):113-6.
doi: 10.5812/ircmj.5138. Epub 2013 Feb 5.

The role of vitamin C in prevention of preterm premature rupture of membranes

Nayereh Ghomian  1 , Leili Hafizi, Zahra Takhti
Affiliations

The role of vitamin C in prevention of preterm premature rupture of membranes

Nayereh Ghomian et al. Iran Red Crescent Med J. 2013 Feb.

Abstract

Background: Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. History of PPROM is a risk factor of recurrent PPROM. Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes.

Objectives: The aim of this study is to evaluate the role of vitamin C supplementation in prevention of PPROM in women with a positive history of PPROM.

Patients and methods: This clinical trial study was performed on 170 pregnant women with the history of PPROM, with singleton pregnancy and gestational age 14 weeks in Imam-Reza Hospital, Mashhad University of Medical Sciences during 2008 to 2010. They were randomly divided into two groups. The case patients received 100 mg vitamin C daily from 14th weeks of gestation. PPROM occurrence was compared between two groups as an indicator of the protective effect of vitamin C supplements.

Results: PPROM occurred in 44.7% of controls and 31.8% of cases (P < 0.05). PROM occurred in 34.1% of controls and 18.8% of cases (P < 0.05). Pregnancy was terminated at term gestation in 21.2% of controls and 49.4% of cases (P < 0.05). Rupture of membranes was significantly decreased in the case group.

Conclusions: Vitamin C supplementations after 14th weeks of gestation can prevent from PPROM in women with the history of PPROM.

Keywords: Ascorbic Acid; Fetal Membranes, Premature Rupture; Pregnancy; Prevention and Control.

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References

    1. Siega-Riz Anna Maria, Promislow Joanne HE, Savitz David A, Thorp John M, McDonald Thad. Vitamin C intake and the risk of preterm delivery. American journal of obstetrics and gynecology. 2003;189(2):519–525. - PubMed
    1. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Management of preterm labor. Williams obstetrics. 23th ed. New york: MC Graw Hill; 2010. pp. 232–47.
    1. Mercer BM. Premature rupture of the membrane. In: Petraglia F, StrauSS GF, Gabbe SG, Wises G, editors. Complicated Pregnancy. 4th ed. London: Informa health care; 2007. pp. 713–27.
    1. Parry S, Strauss JF, 3rd. Premature rupture of the fetal membranes. N Engl J Med. 1998;338(10):663–70. doi: 10.1056/NEJM199803053381006. - DOI - PubMed
    1. Malak TM, Ockleford CD, Bell SC, Dalgleish R, Bright N, Macvicar J. Confocal immunofluorescence localization of collagen types I, III, IV, V and VI and their ultrastructural organization in term human fetal membranes. Placenta. 1993;14(4):385–406. - PubMed

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