Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep;120(9):1909-14.
doi: 10.1016/j.ophtha.2013.02.005. Epub 2013 May 15.

Choroidal thickness measurement in myopic eyes by enhanced depth optical coherence tomography

Mary Ho  1 , David T L Liu, Vesta C K Chan, Dennis S C Lam
Affiliations

Choroidal thickness measurement in myopic eyes by enhanced depth optical coherence tomography

Mary Ho et al. Ophthalmology. 2013 Sep.

Abstract

Purpose: To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI).

Design: A cross-sectional study.

Participants: Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated.

Methods: Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm intervals of the sections. The CT was measured at the subfoveal region in a horizontal fashion, 3 mm temporal to fovea and 3 mm nasal to fovea.

Main outcome measures: Correlations among CT with age, refractive error in diopters, and visual acuity in logarithm of the minimum angle of resolution (logMAR) were analyzed with linear mixed models.

Results: The mean age of the 56 patients was 50.4 years (± 2.03 years standard deviation; interquartile range [IQR], 42-62 years), and the mean refractive error was -8.7 D (IQR, -6.1 to -11 D). The mean subfoveal CT was 118 μm (± 68 μm) and correlated negatively with age (P = 0.032) and refractive error (P = 0.011). Regression analysis suggested that subfoveal CT decreased by 11.9 μm for each decade of life and by 6.205 μm for each diopter of myopia. The subfoveal CT was inversely correlated with the logMAR visual acuity (P = 0.008), and visual acuity improved by 0.02 (logMAR) in a 10-μm increase in CT.

Conclusions: Choroidal thickness decreases with age and severity of myopia. Visual acuity decreases in line with decreasing subfoveal CT. A reduction in CT is related to aging and the severity of myopia, whereas visual acuity depends on subfoveal CT. Our study supports the theory that choroidal abnormality may play a key role in the pathogenesis of myopic degeneration.

Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

PubMed Disclaimer