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Comment
. 2013 May 15;13(5):507-508.
doi: 10.1016/j.chom.2013.05.002.

Bacterial type 6 secreted phospholipases play family feud

Deborah A Hogan  1 , John H Hammond  2
Affiliations
Comment

Bacterial type 6 secreted phospholipases play family feud

Deborah A Hogan et al. Cell Host Microbe. .

Abstract

Secreted bacterial phospholipases play many important roles in host-pathogen interactions. In a recent study, Russell et al. (2013) revealed a new role for highly conserved proteobacterial phospholipases in bacterium-bacterium interactions.

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Figures

Figure 1
Figure 1. Overview of Type 6 secretion system-mediated transfer of Tle proteins from donor cells to effector cells
In the donor cell, effectors are neutralized by an immunity protein. It is predicted that Tle proteins act in the periplasm of target cells, and it is not yet known if Tle lipases act on periplasm-exposed faces of the inner membrane, outer membrane, or both membranes. It also remains to be determined whether cell death results from a loss of membrane integrity, or due to perturbation of other pathways triggered by phospholipase activity.
See this image and copyright information in PMC

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References

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