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Review
. 2013 Oct;1829(10):981-6.
doi: 10.1016/j.bbagrm.2013.05.002. Epub 2013 May 16.

The histone LSD1 demethylase in stemness and cancer transcription programs

Stefano Amente  1 , Luigi Lania, Barbara Majello
Affiliations
Free article
Review

The histone LSD1 demethylase in stemness and cancer transcription programs

Stefano Amente et al. Biochim Biophys Acta. 2013 Oct.
Free article

Abstract

DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a relevant player in the regulation of a broad spectrum of biological processes including development, cellular differentiation, embryonic pluripotency and cancer. Here, we review recent insights on the role of LSD1 activity in chromatin regulatory complexes, its functional role in the epigenetic changes during embryonic development, in the establishment and maintenance of stemness and during cancer progression.

Keywords: Cancer; Chromatin; Histone modification; LSD1; Stem cell.

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