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. 2013:49:216-23.

Resistance reconstructed estimation of total peripheral resistance from computationally derived cardiac output - biomed 2013

Labarron K Hill  1 , John J Sollers Iii, Julian F Thayer
Affiliations

Resistance reconstructed estimation of total peripheral resistance from computationally derived cardiac output - biomed 2013

Labarron K Hill et al. Biomed Sci Instrum. 2013.

Abstract

Efficient functioning of the peripheral vasculature is an essential component in healthy cardiovascular regulation. Alterations in this functioning have been linked to the etiology and pathophysiological course of cardiovascular disease (CVD), especially hypertension. Given its significant role in the maintenance of both healthy and pathological blood pressure, total peripheral resistance (TPR), an index of the vasoconstrictive and elastic properties of the peripheral vasculature, has received much attention in this regard. However, obtaining a reliable estimate of TPR remains a complex and costly endeavor, primarily due to the necessity for sophisticated instrumentation as well as associated limitations in deriving cardiac output (CO). We have previously described a simple estimation method for CO using only arterial blood pressure and heart rate (Hill et al, 2012). In the present study we extend this technique to the estimation of TPR using beat-to-beat blood pressure data from the same sample of 67 young (mean age = 20.04± 2.8), healthy men (n = 30) and women (n = 37). Estimated TPR (TPRest) was calculated from the computationally-derived estimate of CO and mean arterial pressure (MAP). Correlation between TPR obtained via the validated Model-Flow technique and TPRest was moderate (r =.73, p <. 000) and stronger in men (r =.78, p <. 000) compared to women (r =.66, p <. 001). These data further suggest that reconstructed measures of hemodynamic functioning may be validly and adequately estimated from limited data sources.

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Figures

Figure 1
Figure 1
Scatterplot of TPR & TPRest: All Note: Data for 2 participants excluded due to missing gender code.
Figure 2
Figure 2
Scatterplot of TPR & TPRest: Males Note: Data for 2 participants excluded due to missing gender code.
Figure 3
Figure 3
Scatterplot of TPR & TPRest: Females Note: Data for 2 participants excluded due to missing gender code.
Figure 4
Figure 4
Bland-Altman plot: TPR & TPRest: All Note: Data for 2 participants excluded due to missing gender code.
Figure 5
Figure 5
Bland-Altman plot: TPR & TPRest: Males Note: Data for 2 participants excluded due to missing gender code.
Figure 6
Figure 6
Bland-Altman plot: TPR & TPRest: Females Note: Data for 2 participants excluded due to missing gender code.
Figure 7
Figure 7
Mean TPR & TPRest across a series of laboratory tasks.
Figure 8
Figure 8
Difference Scores (Task – Baseline) for TPR & TPRest across a series of laboratory tasks. Note: Plotted values represent data averaged across all subjects.
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References

    1. Mittal BV, Singh AK. Hypertension in the Developing World: Challenges and Opportunities. American Journal of Kidney Diseases. 2010;55(3):590–598. - PubMed
    1. Julius S, Pascual AV, Sannerstedt R, Mitchell C. Relationship Between Cardiac Output and Peripheral Resistance in Borderline Hypertension. Circulation. 1971;43(3):382–90. - PubMed
    1. Julius S. Transition from high cardiac output to elevated vascular resistance in hypertension. American Heart Journal. 1988;116(2):600–606. - PubMed
    1. Thayer JF, Hansen AL, Johnsen BH. Noninvasive Assessment of Autonomic Influences on the Heart: Impedance Cardiography and Heart Rate Variability. In: Gallo LC, Lueken LJ, editors. Handbook of Physiological Research methods in Health Psychology. Sage Publications; 2007. pp. 183–209.
    1. Guyton, Hall . Textbook of Medical Physiology. Tenth Edition W.B. Saunders Co.; 2001.

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