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Comment
. 2013 May 31;340(6136):1049-50.
doi: 10.1126/science.1239119. Epub 2013 May 16.

Point-counterpoint. Patient autonomy and incidental findings in clinical genomics

Susan M Wolf  1 , George J Annas, Sherman Elias
Affiliations
Comment

Point-counterpoint. Patient autonomy and incidental findings in clinical genomics

Susan M Wolf et al. Science. .

Abstract

In spite of the centrality of informed consent in clinical genetics and genomics, new recommendations from the American College of Medical Genetics and Genomics (ACMG) call for laboratories and clinicians to test for and report specific genetic incidental findings, even when the patient does not consent to the testing or disclosure and even when the patient is a child.

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Comment in

  • Call for prudence in whole-genome testing.
    van El CG, Dondorp WJ, de Wert GM, Cornel MC. van El CG, et al. Science. 2013 Aug 30;341(6149):958-9. doi: 10.1126/science.341.6149.958-b. Science. 2013. PMID: 23990543 No abstract available.

Comment on

  • Point-counterpoint. Ethics and genomic incidental findings.
    McGuire AL, Joffe S, Koenig BA, Biesecker BB, McCullough LB, Blumenthal-Barby JS, Caulfield T, Terry SF, Green RC. McGuire AL, et al. Science. 2013 May 31;340(6136):1047-8. doi: 10.1126/science.1240156. Epub 2013 May 16. Science. 2013. PMID: 23686340 Free PMC article. No abstract available.

References

    1. Green RC, Berg JS, Grody WW, Kalia SS, Kork BR, et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet. Med. 2013 http://www.acmg.net/AM/Template.cfm?Section=Home3. - PMC - PubMed
    1. Kohane IS, Mays DR, Altman RB. The incidentalome: a threat to genomic medicine. JAMA. 2006;296:212–215. - PubMed
    1. Wolf SM, Lawrenz FP, Nelson CA, Kahn JP, Cho MK, et al. Managing incidental findings in human subjects research: analysis and recommendations. J. Law Med., Ethics. 2008;36:219–248. - PMC - PubMed
    1. Wolf SM, Crock BN, Van Ness B, Lawrenz FP, Kahn JP, et al. Managing incidental findings and research results in genomic research involving biobanks and archived data sets. Genet. Med. 2012;14:361–384. - PMC - PubMed
    1. Elias S, Annas GJ. Generic consent for genetic screening. N. Engl. J. Med. 1994;330:1611–1613. - PubMed

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