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Review
. 2013 Jun;36(2):245-60.
doi: 10.1016/j.psc.2013.02.004. Epub 2013 Apr 11.

Antidepressant overdose-induced seizures

Bryan S Judge  1 , Landen L Rentmeester
Affiliations
Review

Antidepressant overdose-induced seizures

Bryan S Judge et al. Psychiatr Clin North Am. 2013 Jun.

Abstract

Treating patients with psychiatric problems can present numerous challenges for clinicians. The deliberate self-ingestion of antidepressants is one such challenge frequently encountered in hospitals throughout the United States. This review focuses on 1) the classes of antidepressants, their pharmacologic properties, and some of the proposed mechanism(s) for antidepressant overdose-induced seizures; 2) the evidence for seizures caused by antidepressants in overdose; 3) management strategies for patients who have intentionally or unintentionally overdosed on an antidepressant, or who have experienced an antidepressant overdose-induced seizure.

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