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Multicenter Study
. 2014 Mar;31(3):223-30.
doi: 10.1055/s-0033-1345264. Epub 2013 May 20.

Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

Girija Natarajan  1 , Yvette R Johnson  2 , Beverly Brozanski  3 , Kathryn N Farrow  4 , Isabella Zaniletti  5 , Michael A Padula  6 , Jeanette M Asselin  7 , David J Durand  7 , Billie L Short  8 , Eugenia K Pallotto  9 , Francine D Dykes  10 , Kristina M Reber  11 , Jacquelyn R Evans  6 , Karna Murthy  4 ; Children's Hospital Neonatal Consortium Executive Board and Study Group
Affiliations
Multicenter Study

Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

Girija Natarajan et al. Am J Perinatol. 2014 Mar.

Abstract

Objectives: To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others.

Study design: Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND).

Results: Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01).

Conclusions: Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.

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Figures

Fig. 1
Fig. 1
Flowchart for study cohort and outcomes. Abbreviation: sBPD, severe bronchopulmonary dysplasia.
See this image and copyright information in PMC

References

    1. Ehrenkranz RA, Das A, Wrage LA, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early nutrition mediates the influence of severity of illness on extremely LBW infants. Pediatr Res. 2011;69:522–529. - PMC - PubMed
    1. Martin CR, Brown YF, Ehrenkranz RA, et al. Extremely Low Gestational Age Newborns Study Investigators. Nutritional practices and growth velocity in the first month of life in extremely premature infants. Pediatrics. 2009;124:649–657. - PMC - PubMed
    1. Ehrenkranz RA, Younes N, Lemons JA, et al. Longitudinal growth of hospitalized very low birth weight infants. Pediatrics. 1999;104(2 Pt 1):280–289. - PubMed
    1. Stoll BJ, Hansen NI, Bell EF, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126:443–456. - PMC - PubMed
    1. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723–1729. - PubMed

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