Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Jul;92(7 Suppl):16S-22S.
doi: 10.1177/0022034513484336. Epub 2013 May 20.

Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial

T J Hilton  1 , J L Ferracane, L Mancl; Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NWP)
Collaborators, Affiliations
Randomized Controlled Trial

Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial

T J Hilton et al. J Dent Res. 2013 Jul.

Abstract

This practice-based, randomized clinical trial evaluated and compared the success of direct pulp capping in permanent teeth with MTA (mineral trioxide aggregate) or CaOH (calcium hydroxide). Thirty-five practices in Northwest PRECEDENT were randomized to perform direct pulp caps with either CaOH (16 practices) or MTA (19 practices). Three hundred seventy-six individuals received a direct pulp cap with CaOH (n = 181) or MTA (n = 195). They were followed for up to 2 yrs at regular recall appointments, or as dictated by tooth symptoms. The primary outcomes were the need for extraction or root canal therapy. Teeth were also evaluated for pulp vitality, and radiographs were taken at the dentist's discretion. The probability of failure at 24 mos was 31.5% for CaOH vs. 19.7% for MTA (permutation log-rank test, p = .046). This large randomized clinical trial provided confirmatory evidence for a superior performance with MTA as a direct pulp-capping agent as compared with CaOH when evaluated in a practice-based research network for up to 2 yrs.

Trial registration: ClinicalTrials.gov NCT00812887.

Keywords: clinical research; dental cavity liner; dental pulp; dental pulp exposure; pulp-capping agents; sodium hypochlorite.

PubMed Disclaimer

Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1.
Figure 1.
Patient flow diagram.
Figure 2.
Figure 2.
Kaplan-Meier failure curve by treatment group.
See this image and copyright information in PMC

References

    1. Accorinte Mde L, Holland R, Reis A, Bortoluzzi MC, Murata SS, Dezan E, Jr, et al. (2008). Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth. J Endod 34:1-6. - PubMed
    1. Aeinehchi M, Eslami B, Ghanbariha M, Saffar AS. (2003). Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J 36:225-231. - PubMed
    1. Aguilar P, Linsuwanont P. (2011). Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod 37:581-587. - PubMed
    1. Barthel CR, Levin LG, Reisner HM, Trope M. (1997). TNF-alpha release in monocytes after exposure to calcium hydroxide treated Escherichia coli LPS. Int Endod J 30:155-159. - PubMed
    1. Baume LJ, Holz J. (1981). Long term clinical assessment of direct pulp capping. Int Dent J 31:251-260. - PubMed

Publication types

MeSH terms

Associated data

LinkOut - more resources