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. 2013;10(5):e1001446.
doi: 10.1371/journal.pmed.1001446. Epub 2013 May 14.

Setting research priorities to reduce mortality and morbidity of childhood diarrhoeal disease in the next 15 years

Kerri Wazny  1 , Alvin Zipursky, Robert Black, Valerie Curtis, Christopher Duggan, Richard Guerrant, Myron Levine, William A Petri Jr, Mathuram Santosham, Rebecca Scharf, Philip M Sherman, Evan Simpson, Mark Young, Zulfiqar A Bhutta
Affiliations

Setting research priorities to reduce mortality and morbidity of childhood diarrhoeal disease in the next 15 years

Kerri Wazny et al. PLoS Med. 2013.

Abstract

Zulfi Bhutta and colleagues lay out research priorities for global child diarrheal disease over the next 15 years, which they developed using the Child Health and Nutrition Research Initiative (CHNRI) method.

Please see later in the article for the Editors' Summary

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Conflict of interest statement

VC is the principal investigator on a research grant from Unilever Plc that aims to understand behaviour associated with handwashing with soap. ML holds a patent as co-inventor of live oral cholera vaccine strain CVD 103-HgR, which has been licensed by the vaccine company PaxVax, who are supporting the clinical development program towards national regulatory agency licensure of the vaccine. MS is on the editorial board of PLOS Medicine. PMS sits on the Medical Scientific Advisory Board for Alberta Inflammatory Bowel Disease Research Consortium. PMS sits on Medical Advisory Boards for Abbott Nutrition, Mead Johnson Nutrition, and Proctor and Gamble; PMS sits on the Research Advisory Board for Antibe Therapeutics and is a stockholder. PMS also currently holds a research contract from Institut Rosell-Lallemand Inc. (Montreal, Quebec, Canada) to study the effectiveness of a short-chain fructo-oligosaccharide (sc-FOS) prebiotic preparation in ameliorating intestinal epithelial injury in response to bacterial enteric pathogens using both polarized model epithelia in tissue culture and a murine model of colitis, undertaken in the Research Institute at the Hospital for Sick Children in Toronto, Canada where the funds are held in a research funding account. The studies are also supported by research funding from the Canadian Institutes of Health Research (2008–2013) and previously by a Fay Shapiro-Cutler grant-in-aid from the Crohn's and Colitis Foundation of Canada (2007–2010). ZAB is on the editorial board of PLOS Medicine, and is the principal investigator of the grant from the Bill & Melinda Gates Foundation to coordinate the development of the Global Action Plan for Pneumonia and Diarrhoea. All other authors report no competing interests.

Figures

Figure 1
Figure 1. Ten “teams” of research focus and distribution of research questions into Description, Discovery, Development, and Delivery areas.
See this image and copyright information in PMC

References

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    1. Fontaine O, Kosek M, Bhatnagar S, Boschi-Pinto C, Chan KY, et al. (2009) Setting research priorities to reduce global mortality from childhood diarrhoea by 2015. PLoS Med 6: e1000041 doi:10.1371/journal.pmed.1000041. - DOI - PMC - PubMed
    1. Jones G, Steketee RW, Black RE, Bhutta ZA, Morris SS, et al. (2003) How many child deaths can we prevent this year? Lancet 362: 65–71. - PubMed

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