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. 2013:2013:538017.
doi: 10.1155/2013/538017. Epub 2013 Apr 18.

Endothelial activation microparticles and inflammation status improve with exercise training in african americans

Dianne M Babbitt  1 , Keith M Diaz, Deborah L Feairheller, Kathleen M Sturgeon, Amanda M Perkins, Praveen Veerabhadrappa, Sheara T Williamson, Jan Kretzschmar, Chenyi Ling, Hojun Lee, Heather Grimm, Sunny R Thakkar, Deborah L Crabbe, Mohammed A Kashem, Michael D Brown
Affiliations

Endothelial activation microparticles and inflammation status improve with exercise training in african americans

Dianne M Babbitt et al. Int J Hypertens. 2013.

Abstract

African Americans have the highest prevalence of hypertension in the world which may emanate from their predisposition to heightened endothelial inflammation. The purpose of this study was to determine the effects of a 6-month aerobic exercise training (AEXT) intervention on the inflammatory biomarkers interleukin-10 (IL-10), interleukin-6 (IL-6), and endothelial microparticle (EMP) CD62E+ and endothelial function assessed by flow-mediated dilation (FMD) in African Americans. A secondary purpose was to evaluate whether changes in IL-10, IL-6, or CD62E+ EMPs predicted the change in FMD following the 6-month AEXT intervention. A pre-post design was employed with baseline evaluation including office blood pressure, FMD, fasting blood sampling, and graded exercise testing. Participants engaged in 6 months of AEXT. Following the AEXT intervention, all baseline tests were repeated. FMD significantly increased, CD62E+ EMPs and IL-6 significantly decreased, and IL-10 increased but not significantly following AEXT. Changes in inflammatory biomarkers did not significantly predict the change in FMD. The change in VO2 max significantly predicted the change in IL-10. Based on these results, AEXT may be a viable, nonpharmacological method to improve inflammation status and endothelial function and thereby contribute to risk reduction for cardiovascular disease in African Americans.

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Figures

Figure 1
Figure 1
Measures of brachial artery diameter and endothelial function before and after AEXT. The upper panel (a) shows brachial artery diameter at baseline and at 1-minute post-ischemia pre- and post-AEXT. The lower panel (b) shows FMD% pre- and post-AEXT. Bars are expressed as mean ± SEM. **Denotes significant differences pre- versus post-AEXT; P < 0.01.
Figure 2
Figure 2
Inflammatory biomarkers before and after AEXT. The upper panel (a) shows CD62E+ EMPs pre- and post-AEXT. The middle panel (b) shows IL-6 pre- and post-AEXT. The lower panel (c) shows IL-10 pre- and post-AEXT. Bars are expressed as mean ± SEM. *Denotes significant differences pre- versus post-AEXT; P < 0.05. **Denotes significant differences pre- versus post-AEXT; P < 0.01.
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