Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:489865.
doi: 10.1155/2013/489865. Epub 2013 Apr 15.

Psychiatric morbidity and other factors affecting treatment adherence in pulmonary tuberculosis patients

Argiro Pachi  1 , Dionisios Bratis, Georgios Moussas, Athanasios Tselebis
Affiliations

Psychiatric morbidity and other factors affecting treatment adherence in pulmonary tuberculosis patients

Argiro Pachi et al. Tuberc Res Treat. 2013.

Abstract

As the overall prevalence of TB remains high among certain population groups, there is growing awareness of psychiatric comorbidity, especially depression and its role in the outcome of the disease. The paper attempts a holistic approach to the effects of psychiatric comorbidity to the natural history of tuberculosis. In order to investigate factors associated with medication nonadherence among patients suffering from tuberculosis, with emphasis on psychopathology as a major barrier to treatment adherence, we performed a systematic review of the literature on epidemiological data and past medical reviews from an historical perspective, followed by theoretical considerations upon the relationship between psychiatric disorders and tuberculosis. Studies reporting high prevalence rates of psychiatric comorbidity, especially depression, as well as specific psychological reactions and disease perceptions and reviews indicating psychiatric complications as adverse effects of anti-TB medication were included. In sum, data concerning factors affecting medication nonadherence among TB patients suggested that better management of comorbid conditions, especially depression, could improve the adherence rates, serving as a framework for the effective control of tuberculosis, but further studies are necessary to identify the optimal way to address such issues among these patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Consort diagram of the method.
See this image and copyright information in PMC

References

    1. Herchline TE, Cunha BA, Chavis PS, et al. Tuberculosis. Medscape Reference, WebMD, Updated: March, 2012.
    1. Martin P. Tuberculosis at the end of the century. MedDigest. 1996;22:10–11.
    1. Small PM. Tuberculosis research: balancing the portfolio. Journal of the American Medical Association. 1996;276(18):1512–1513. - PubMed
    1. Rajeswari R, Balasubramanian R, Muniyandi M, Geetharamani S, Thresa X, Venkatesan P. Socio-economic impact of tuberculosis on patients and family in India. International Journal of Tuberculosis and Lung Disease. 1999;3(10):869–877. - PubMed
    1. World Health Organization. Global Tuberculosis Control 2010. Geneva, Switzerland: World Health Organization; 2010. http://www.who.int/tb/publications/global_report/en/index.html.

LinkOut - more resources