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. 2013 Apr 11:2013:675051.
doi: 10.1155/2013/675051. Print 2013.

Cell Proliferation (KI-67) Expression Is Associated with Poorer Prognosis in Nigerian Compared to British Breast Cancer Women

Ayodeji O J Agboola  1 , Adekumbiola A F Banjo, Charles C Anunobi, Babatunde Salami, Mopelola Deji Agboola, Adewale A Musa, Christopher C Nolan, Emad A Rakha, Ian O Ellis, Andrew R Green
Affiliations

Cell Proliferation (KI-67) Expression Is Associated with Poorer Prognosis in Nigerian Compared to British Breast Cancer Women

Ayodeji O J Agboola et al. ISRN Oncol. .

Abstract

Background. Black women with breast cancer (BC) in Nigeria have higher mortality rate compared with British women. This study investigated prognostic features of cell proliferation biomarker (Ki-67) in Nigerian breast cancer women. Materials and Methods. The protein expression of Ki-67 was investigated in series of 308 Nigerian women, prepared as a tissue microarray (TMA), using immunohistochemistry. Clinic-pathological parameters, biomarkers, and patient outcome of tumours expressing Ki-67 in Nigerian women were correlated with UK grade-matched series. Results. A significantly larger proportion of breast tumours from Nigerian women showed high Ki-67 expression. Those tumours were significantly correlated with negative expression of the steroid hormone receptors (ER and PgR), p21, p27, E-cadherin, BRCA-1, and Bcl-2 (all P < 0.001), but positively associated with EGFR (P = 0.003), p53, basal cytokeratins: CK56, CK14, triple negative, and basal phenotype using Nielsen's classification (all P < 0.001) compared to UK women. Multivariate analyses showed that race was also associated with BCSS independent of tumour size, lymph node status, and ER status. Conclusion. Ki-67 expression was observed to have contributed to the difference in the BCSS in Nigerian compared with British BC women. Therefore, targeting Ki-67 in the indigenous black women with BC might improve the patient outcome in the black women with BC.

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Figures

Figure 1
Figure 1
(a) and (b) show positive and negative immunoreactivity of KI-67 in Nigerian breast cancer magnification ×20.
Figure 2
Figure 2
(a) and (b) show KI-67 positive expression in relation to BCSS and DFI between UK and Nigerian series.
See this image and copyright information in PMC

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