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Case Reports
. 2012 Sep;9(3):197-201.
doi: 10.7497/j.issn.2095-3941.2012.03.008.

Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review

Jin-Yan Hao  1 , Cui-Cui Yang, Fang-Fang Liu, Yi-Ling Yang, Shuai Li, Wei-Dong Li, Ya-Qing Li, Rong-Gang Lang, Yu Fan, Estifanos Paulos, Xin-Min Zhang, Li Fu
Affiliations
Case Reports

Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review

Jin-Yan Hao et al. Cancer Biol Med. 2012 Sep.

Abstract

The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis. Primary tumors may arise from any ectopic breast tissue. Accessory breast cancer occurring concurrently with primary invasive breast cancer is extremely rare. Two such cases were reported in this article. One was a 43-year-old Chinese female who exhibited bilateral breast cancer (invasive ductal carcinoma, not otherwise specified, IDC-NOS) and an accessory breast carcinoma (IDC-NOS) incidentally identified in her left axilla. The ectopic breast tissue in her right axilla presented with adenosis. The patient was surgically treated, followed by postoperative docetaxel epirubicin (TE) chemotherapy. The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified. The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

Keywords: accessory breast cancer; bilateral; invasive breast cancer; occurring concurrently; primary.

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Conflict of interest statement

No potential conflicts of interest are disclosed.

Figures

Figure 1
Figure 1
Case one. Mastectomy specimens and the dissection method: right (A) and left (B).
Figure 2
Figure 2
Ductal carcinoma in situ was admixed with the IDC-NOS in the right breast (A) (H&E stain, ×100). Ductal carcinoma in situ was adjacent to the IDC-NOS in the left breast (B) (H&E stain, ×40).
Figure 3
Figure 3
The right axillary accessory breast tissue exhibited adenosis (A) (H&E stain, ×100). IDC-NOS (lower left) and normal breast tissue (middle to upper) were identified in the left axillary accessory breast tissue (B) (H&E stain, ×40). The enlargement of the normal breast tissue in B is illustrated in C (H&E stain, ×100).
Figure 4
Figure 4
Case two. Breast mastectomy specimens and the dissection method: right (A) and left (B).
Figure 5
Figure 5
The tumors in the right (A) (H&E stain, ×40) and left (B) (H&E stain, ×100) breasts were apocrine carcinoma and chemotherapy reaction II. GCDFP-15 protein was positive in the right (C) and left (D) tumors (IHC LSAB, ×100).
Figure 6
Figure 6
Ductal carcinoma in situ was adjacent to the apocrine carcinoma of the right breast (A) (H&E stain, ×40). Ductal carcinoma in situ was admixed with the apocrine carcinoma of the left breast (B) (H&E stain, ×40).
Figure 7
Figure 7
The right axillary mass consisted of IDC-NOS (upper right) with chemotherapy reaction II, adjacent to benign ectopic breast tissue (upper left), (H&E stain, ×40).
See this image and copyright information in PMC

References

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