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. 2013:2013:948257.
doi: 10.1155/2013/948257. Epub 2013 Feb 25.

Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Lepr (fa) Rat: A New Obese Type 2 Diabetic Model

Yusuke Kemmochi  1 , Kenji Fukui, Mimi Maki, Shuichi Kimura, Yukihito Ishii, Tomohiko Sasase, Katsuhiro Miyajima, Takeshi Ohta
Affiliations

Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Lepr (fa) Rat: A New Obese Type 2 Diabetic Model

Yusuke Kemmochi et al. J Diabetes Res. 2013.

Abstract

Spontaneously Diabetic Torii Lepr (fa) (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. Both male and female SDT fatty rats show overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with SDT rats. With early incidence of diabetes mellitus, diabetic complications, such as nephropathy, retinopathy, and neuropathy, in SDT fatty rats were seen at younger ages compared to those in the SDT rats. In this paper, we overview pathophysiological features in SDT fatty rats and also describe new insights regarding the hematology, blood pressure, renal complications, and sexual dysfunction. The SDT fatty rats showed an increase of leukocytes, especially the monocyte count, prominent hypertension associated with salt drinking, end-stage renal disease with aging, and hypogonadism. Unlike other diabetic models, the characteristic of SDT fatty rat is to present an incidence of diabetes in females, hypertension, and retinopathy. SDT fatty rat is a useful model for analysis of various metabolic disorders and the evaluation of drugs related to metabolic disease.

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Figures

Figure 1
Figure 1
Computed tomography analysis at 12 weeks of age (representative tomogram). (a) SDT fatty rat; (b) SDT rat. Yellow: subcutaneous fat; red: visceral fat; blue: lean [14].
Figure 2
Figure 2
Changes in body weights (a) and serum parameters (b) glucose; (c) triglyceride; (d) total cholesterol) in SDT fatty rats, pair-fed SDT fatty rats, and SDT rats. Data represent mean ± standard deviation (n = 6). ## P < 0.01: significantly different from SDT fatty rat. **P < 0.01: significantly different from SDT rat.
Figure 3
Figure 3
Histological analysis, HE stain. Pathological findings such as atrophy and fibrosis in pancreatic islets of female SDT fatty rat at 24 weeks of age. Bar = 50 μm.
Figure 4
Figure 4
Histological analysis. HE stain. Severely progressed glomerular and tubulointerstitial lesions in male SDT fatty rat at 60 weeks of age There are completely sclerotic glomeruli and atrophic tubules with many inflammatory cells in the interstitum. Bar = 100 μm.
Figure 5
Figure 5
Changes in MNCV at 8 (a), 24 (b), and 40 (c) weeks of age in SD rats and SDT fatty rats. Data represent mean ± standard deviation (n = 5). *P < 0.05, **P < 0.01: significantly different from SD rat.
Figure 6
Figure 6
Changes in serum osteocalcin (a), (c) and urine deoxypyridinoline (b), (d) in SD rats and SDT fatty rats. Data represent mean ± standard deviation (Male: n = 5, Female: n = 10). *P < 0.05, **P < 0.01: significantly different from SD rat.
Figure 7
Figure 7
Changes in BMD (a), (c) and BMC (b), (d) in SD rats and SDT fatty rats. Data represent mean ± standard deviation (Male: n = 5, Female: n = 10). *P < 0.05, **P < 0.01: significantly different from SD rat.
Figure 8
Figure 8
Histological analysis of uterus, HE stain. (a) SD rats and (b) SDT fatty rats at 12 weeks of age. Bar = 1 mm [26].
Figure 9
Figure 9
Histological analysis of vagina, HE stain. (a) SD rats and (b) SDT fatty rats at 12 weeks of age. Bar = 200 μm [26].
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