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. 2013 Dec;49(3):485-8.
doi: 10.1016/j.transci.2013.04.040. Epub 2013 May 18.

Risk factors for a poor hematopoietic stem cell mobilization

Ayhan Donmez  1 , Fergun Yilmaz, Nihal Gokmen, Murat Tombuloglu
Affiliations

Risk factors for a poor hematopoietic stem cell mobilization

Ayhan Donmez et al. Transfus Apher Sci. 2013 Dec.

Abstract

Poor mobilization is an important problem in autologous stem cell transplantation. We retrospectively reviewed the data of 165 mobilized patients to identify possible risk factors for a poor stem cell mobilization. 27 patients (16.4%) were categorized as poorly mobilized. The poor mobilization ratio differed according to diagnosis (lymphoma: 25.4%, acute leukemia: 15.4%, amyloidosis: 14.3%, and multiple myeloma: 9.6%). Being diagnosed as lymphoma (odds ratio [OR]=6.02, p=0.001), advanced age (OR=1.05, p=0.007) and increased weight (OR=1.03, p=0.03) were found as possible risk factors. Being diagnosed as lymphoma was shown to be the most important risk factor for a poor mobilization. Leukapheresis staff should be aware of the increased risk of a poor mobilization in lymphoma patients and remobilization methods should be considered from the beginning.

Keywords: Hematopoietic stem cell mobilization; Poor mobilization; Risk factors.

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