Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;26(4):310-2.
doi: 10.1007/BF02897237.

Interaction of antiestrogens with binding sites for muscarinic cholinergic drugs and calcium channel blockers in cell membranes

S Batra  1
Affiliations

Interaction of antiestrogens with binding sites for muscarinic cholinergic drugs and calcium channel blockers in cell membranes

S Batra. Cancer Chemother Pharmacol. 1990.

Abstract

The interaction of tamoxifen and clomifene with membrane binding sites for the cholinergic ligand quinuclidinyl benzilate (QNB) and the dihydropyridine calcium antagonist nitrendipine was studied. Both tamoxifen and clomifene competed with [3H]-QNB and [3H]-nitrendipine for their binding to the receptor in the membrane fractions from the urinary bladder and myometrium. The extent of inhibition as judged by the Ki values for both antiestrogens was similar at both receptor sites. The data suggest that the antiproliferative effects of tamoxifen may involve not only the intracellular estrogen-receptor system but also receptors for neurotransmitters and membrane calcium channels.

PubMed Disclaimer

References

    1. Prostate. 1988;13(1):79-87 - PubMed
    1. Proc Soc Exp Biol Med. 1983 Oct;174(1):16-9 - PubMed
    1. Br J Cancer. 1984 Aug;50(2):199-205 - PubMed
    1. J Biol Chem. 1984 Apr 10;259(7):4223-9 - PubMed
    1. Biochem Biophys Res Commun. 1985 Sep 16;131(2):750-5 - PubMed