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Review
. 2013 Apr 25;14(5):8924-47.
doi: 10.3390/ijms14058924.

Melatonin-based therapeutics for neuroprotection in stroke

Kazutaka Shinozuka  1 , Meaghan Staples, Cesar V Borlongan
Affiliations
Review

Melatonin-based therapeutics for neuroprotection in stroke

Kazutaka Shinozuka et al. Int J Mol Sci. .

Abstract

The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.

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Figures

Figure 1
Figure 1
Schematic illustrations of melatonin therapies for stroke. (a) Exogenous melatonin administration; (b) Transplantation of pineal gland cells secreting melatonin; (c) Transplantation of stem cells expressing melatonin receptors. Combination of these therapies may prove advantageous in abrogating brain damage with stroke.
See this image and copyright information in PMC

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