Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug;56(8):1689-95.
doi: 10.1007/s00125-013-2936-7. Epub 2013 May 23.

Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity

K Mattsson  1 , K Källén, M P Longnecker, A Rignell-Hydbom, L Rylander
Affiliations

Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity

K Mattsson et al. Diabetologia. 2013 Aug.

Abstract

Aims/hypothesis: The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes.

Methods: Data were retrieved from the Medical Birth Register of Sweden for women who were born in 1982 (when smoking data were first registered) or later and who had given birth to at least one child; 80,189 pregnancies were included. The associations between in utero smoking exposure (three categories: non-smokers, 1-9 cigarettes/day [moderately exposed] and >9 cigarettes/day [heavily exposed]) and subsequent gestational diabetes (n = 291), non-gestational diabetes (n = 280) and obesity (n = 7,300) were assessed.

Results: The adjusted ORs (aORs) of gestational diabetes were increased among women who were moderately (1.62, 95% CI 1.24, 2.13) and heavily (1.52, 95% CI 1.12, 2.06) exposed. The corresponding aORs of obesity were 1.36 (95% CI 1.28, 1.44) and 1.58 (95% CI 1.48, 1.68), respectively. A reduced OR for non-gestational diabetes was seen in the offspring of heavy smokers (aOR 0.66, 95% CI 0.45, 0.96).

Conclusions/interpretation: Women exposed to smoking during fetal life were at higher risk of developing gestational diabetes and obesity.

PubMed Disclaimer

Conflict of interest statement

Duality of interests

The authors declare that they have no duality of interests.

References

    1. Cnattingius S. The epidemiology of smoking during pregnancy: Smoking prevalence, maternal characteristics, and pregnancy outcomes. Nicotine & Tobacco Research. 2004;6:S125–S140. - PubMed
    1. Aagaard-Tillery KM, Porter TF, Lane RH, Varner MW, Lacoursiere DY. In utero tobacco exposure is associated with modified effects of maternal factors on fetal growth. Am J Obstet Gynecol. 2008;198:66.e61–66.e66. - PubMed
    1. Ino T. Maternal smoking during pregnancy and offspring obesity: meta-analysis. Pediatr Int. 2010;52:94–99. - PubMed
    1. Oken E, Levitan EB, Gillman MW. Maternal smoking during pregnancy and child overweight: systematic review and meta-analysis. Int J Obes (Lond) 2008;32:201–210. - PMC - PubMed
    1. Behl M, Rao D, Aagaard K, et al. Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review. Environ Health Perspect. 2013;121:170–180. - PMC - PubMed

Publication types

LinkOut - more resources