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Comparative Study
. 2013 Jul;148(7):597-601.
doi: 10.1001/jamasurg.2013.1431.

Long-term outcomes following tumor ablation for treatment of bilateral colorectal liver metastases

Paul J Karanicolas  1 , William R Jarnagin, Mithat Gonen, Scott Tuorto, Peter J Allen, Ronald P DeMatteo, Michael I D'Angelica, Yuman Fong
Affiliations
Comparative Study

Long-term outcomes following tumor ablation for treatment of bilateral colorectal liver metastases

Paul J Karanicolas et al. JAMA Surg. 2013 Jul.

Abstract

Importance: Ablative therapies extend the capability of delivering potentially curative treatment for bilateral hepatic colorectal metastases.

Objective: To compare the long-term effectiveness of ablation with that of resection in patients with bilateral hepatic colorectal metastases.

Design: Review of a prospective database of 2123 operative cases of hepatic colorectal metastases.

Setting: A large institution with expertise in ablation and resection.

Patients: Patients with bilateral colorectal liver metastases undergoing operation with a curative intent. A total of 141 patients had been treated with bilateral resection (BR) and 95 had undergone ablation.

Interventions: Radiofrequency or microwave ablation alone or in combination with resection (A/R) compared with BR.

Main outcomes and measures: We compared tumor characteristics and operative and postoperative outcomes using χ2 or Wilcoxon tests as appropriate and assessed overall survival differences between the 2 groups using the log-rank test.

Results: During the study, 141 patients were treated with BR and 95 patients with A/R. The A/R group was a significantly poorer prognostic group than the BR group as judged by the Clinical Risk Score (P < .01). There was no difference in median operative time (A/R: 280 minutes, BR: 282 minutes; P = .52), but a lower blood loss (A/R: 300 mL, BR: 500 mL; P < .01) and a shorter length of stay (A/R: 7 days, BR: 9 days; P < .01) was achieved in the A/R group. Long-term outcome was not significantly different between the groups (5-year overall survival, A/R: 56%, BR: 49%; P = .16).

Conclusions and relevance: Treatment of bilateral, multiple hepatic metastases with combined resection and ablation was associated with improved perioperative outcomes without compromising long-term survival compared with bilateral resection. Ablative therapies extend the capability of delivering potentially curative treatment for bilateral hepatic colorectal metastases.

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Figures

Figure 1
Figure 1
Distribution of Clinical Risk Score (CRS) in patients treated with bilateral resection or ablation +- resection (p=0.002).
Figure 2
Figure 2
Overall survival in patients treated with bilateral resection or ablation +- resection (p=0.161).
See this image and copyright information in PMC

Comment in

References

    1. Choti MA, Sitzmann JV, Tiburi MF, et al. Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg. 2002;235(6):759–66. - PMC - PubMed
    1. House MG, Ito H, Gonen M, et al. Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution. J Am Coll Surg. 2010;210(5):744–52. 752–5. - PubMed
    1. Nordlinger B, Guiguet M, Vaillant JC, et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer. 1996;77(7):1254–62. - PubMed
    1. Scheele J, Stang R, Altendorf-Hofmann A, et al. Resection of colorectal liver metastases. World J Surg. 1995;19(1):59–71. - PubMed
    1. Tomlinson JS, Jarnagin WR, DeMatteo RP, et al. Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol. 2007;25(29):4575–80. - PubMed

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