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. 1990 Jul;31(7):817-20.
doi: 10.1136/gut.31.7.817.

Enhanced intestinal glucose and alanine transport in cystic fibrosis

P Baxter  1 , J Goldhill, J Hardcastle, P T Hardcastle, C J Taylor
Affiliations

Enhanced intestinal glucose and alanine transport in cystic fibrosis

P Baxter et al. Gut. 1990 Jul.

Abstract

The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.

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