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. 1990 Jul;85(2):241-3.
doi: 10.1007/BF00193204.

Improved fragile site detection with trimethoprim

D A McLean  1 , M J Faed
Affiliations

Improved fragile site detection with trimethoprim

D A McLean et al. Hum Genet. 1990 Jul.

Abstract

The effect of trimethoprim, an inhibitor of dihydrofolate reductase, in demonstrating the presence of fragile sites on human chromosomes was investigated. Lymphocyte cultures with 20 mg/l trimethoprim added at the onset of incubation gave consistently higher frequencies of fragile sites than the other culture regimes tested.

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