Chromatin: a tail of repression
- PMID: 23701691
- DOI: 10.1016/j.cub.2013.04.033
Chromatin: a tail of repression
Abstract
Genetic evidence on the role of specific histone amino acids or their posttranslational modifications in metazoan development has been lacking. A recent study reports that fruit flies carrying histone H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mutations in the enzyme that trimethylates H3K27.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Comment on
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A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.Science. 2013 Feb 8;339(6120):698-9. doi: 10.1126/science.1231382. Science. 2013. PMID: 23393264
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