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. 2009:807-810.
doi: 10.1109/isbi.2009.5193172.

VOXEL-WISE GROUP ANALYSIS OF DTI

Zhexing Liu  1 , Hongtu Zhu, Bonita L Marks, Laurence M Katz, Casey B Goodlett, Guido Gerig, Martin Styner
Affiliations

VOXEL-WISE GROUP ANALYSIS OF DTI

Zhexing Liu et al. Proc IEEE Int Symp Biomed Imaging. 2009.

Abstract

Diffusion tensor MRI (DTI) is now a widely used modality to investigate the fiber tissues in vivo, especially the white matter in brain. An automatic pipeline is described in this paper to conduct a localized voxel-wise multiple-subject group comparison study of DTI. The pipeline consists of 3 steps: 1) Preprocessing, including image format converting, image quality check, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via affine followed by fluid nonlinear registration and warping of all individual DTI images into the common atlas space to achieve voxel-wise correspondence, 3) voxelwise statistical analysis via heterogeneous linear regression and wild bootstrap technique for correcting for multiple comparisons. This pipeline was applied to process data from a fitness and aging study and preliminary results are presented. The results show that this fully automatic pipeline is suitable for voxel-wise group DTI analysis.

Keywords: Diffusion tensor; Group comparison; MRI; Voxel-wise analysis.

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Figures

Fig. 1
Fig. 1
DWI quality control and artifact correction. a. Rigid registration parameters between each gradient and baseline image of the original DWI. b. FA and color coded FA images before eddy-current and motion correction. c. Rigid registration parameters between each gradient and baseline image of the corrected DWI. d. FA and color coded FA images after eddy-current and motion correction.
Fig. 2
Fig. 2
Scheme of unbiased DTI atlas computing
Fig. 3
Fig. 3
Voxel-wise group comparison scheme
Fig. 4
Fig. 4
Voxel analysis results. a. Axial view of significance maps (in red, p<0.05) overlaid on FA images of the unbiased DTI atlas. b. Axial view of correlation significance maps (in red, p<0.05) overlaid on a white matter masked Pearson correlation images. Within the correlation maps, correlation equals 0 where the color is gray as in back ground, white equals 1 and black equals -1. c. and d. are zoomed in views of a. at the Arcuate and Splenium area.
See this image and copyright information in PMC

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