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Editorial
. 2013 Oct;58(4):1210-2.
doi: 10.1002/hep.26497. Epub 2013 Aug 14.

ROS: redux and paradox in fatty liver disease

Orkhontuya Tsedensodnom  1 , Kirsten C Sadler
Affiliations
Editorial

ROS: redux and paradox in fatty liver disease

Orkhontuya Tsedensodnom et al. Hepatology. 2013 Oct.
No abstract available

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Conflict of interest statement

Potential conflict of interest: Nothing to report.

Figures

Fig. 1
Fig. 1
Homeostatic levels of ROS are maintained by GMP levels and are required to prevent steatosis in zebrafish larvae. This simplified schematic illustrates how de novo purine synthesis is linked to hepatic lipid metabolism as revealed by the s850 mutation in the GMP synthetase gene. Adequate supply of GMP in hepatocytes maintains Rac1 in its active form, which indirectly induces homeostatic generation of ROS by way of Nox1,2. This, in turn, promotes activation of Tgh/Ces3, the hydrolase that releases triglycerides from lipid droplets. Inhibition of expression or activity of these players, including blocking ROS by using NAC, induces steatosis. GMP, guanosine monophosphate; IMP, inosine monophosphate; NAC, N-acetyl cysteine; Nox, NADPH oxidase; ROS, reactive oxygen species; Tgh/Ces3, triglyceride hydrolase/carboxylesterase3; XMP, xanthosine monophosphate.
See this image and copyright information in PMC

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References

    1. Nussbaum J, Hasan S, Liu L, Schaub M, McClendon A, Stainier DY, et al. Homeostatic generation of reactive oxygen species protects zebrafish liver from hepatic steatosis. Hepatology. 2013;58:1326–1338. - PMC - PubMed
    1. Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362:1675–1685. - PMC - PubMed
    1. Nguyen-Khac E, Thevenot T, Piquet M-A, Benferhat SØ, Goria O, Chatelain D, et al. Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med. 2011;365:1781–1789. - PubMed
    1. Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M, et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013 Epub ahead of print. - PMC - PubMed
    1. Sadler KC, Amsterdam A, Soroka C, Boyer J, Hopkins N. A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Development. 2005;132:3561–3572. - PubMed

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