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. 2013 Sep;24(9):2439-43.
doi: 10.1093/annonc/mdt188. Epub 2013 May 22.

Bowel perforation in intestinal lymphoma: incidence and clinical features

R Vaidya  1 , T M Habermann, J H Donohue, K M Ristow, M J Maurer, W R Macon, J P Colgan, D J Inwards, S M Ansell, L F Porrata, I N Micallef, P B Johnston, S N Markovic, C A Thompson, G S Nowakowski, T E Witzig
Affiliations

Bowel perforation in intestinal lymphoma: incidence and clinical features

R Vaidya et al. Ann Oncol. 2013 Sep.

Abstract

Background: Perforation is a serious life-threatening complication of lymphomas involving the gastrointestinal (GI) tract. Although some perforations occur as the initial presentation of GI lymphoma, others occur after initiation of chemotherapy. To define the location and timing of perforation, a single-center study was carried out of all patients with GI lymphoma.

Patients and methods: Between 1975 and 2012, 1062 patients were identified with biopsy-proven GI involvement with lymphoma. A retrospective chart review was undertaken to identify patients with gut perforation and to determine their clinicopathologic features.

Results: Nine percent (92 of 1062) of patients developed a perforation, of which 55% (51 of 92) occurred after chemotherapy. The median day of perforation after initiation of chemotherapy was 46 days (mean, 83 days; range, 2-298) and 44% of perforations occurred within the first 4 weeks of treatment. Diffuse large B-cell lymphoma (DLBCL) was the most common lymphoma associated with perforation (59%, 55 of 92). Compared with indolent B-cell lymphomas, the risk of perforation was higher with aggressive B-cell lymphomas (hazard ratio, HR = 6.31, P < 0.0001) or T-cell/other types (HR = 12.40, P < 0.0001). The small intestine was the most common site of perforation (59%).

Conclusion: Perforation remains a significant complication of GI lymphomas and is more frequently associated with aggressive than indolent lymphomas. Supported in part by University of Iowa/Mayo Clinic SPORE CA97274 and the Predolin Foundation.

Keywords: lymphoma; perforation.

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Figures

Figure 1.
Figure 1.
Sites of perforation in 100 perforation events with GI lymphoma (the site was unknown in 2 patients who transitioned to hospice after demonstration of free air in the abdomen on computed tomography imaging).
See this image and copyright information in PMC

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