Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 May 24;112(11):1412-4.
doi: 10.1161/CIRCRESAHA.113.301409.

Small solutions to big problems: microRNAs for cardiac regeneration

Deepak Srivastava  1 , Amy J Heidersbach
Affiliations
Comment

Small solutions to big problems: microRNAs for cardiac regeneration

Deepak Srivastava et al. Circ Res. .

Abstract

Heart disease is a major cause of morbidity and mortality in the developed world. Patient recovery after cardiac injury is hampered by the extremely limited regenerative capacity of the adult mammalian heart. In addition to cell-based approaches and in situ cardiac reprogramming, significant interest has been focused on genetic and small molecule–based strategies to enhance endogenous cardiomyocyte proliferative potential. A recent study in Nature suggests, for the first time, that microRNAs may have the ability to induce cardiomyocyte proliferation and cardiac regeneration in adult mice.

PubMed Disclaimer

Figures

Figure 1
Figure 1. MicroRNA regulation of cardiac regeneration
miRNAs regulate many processes in cardiac regeneration, including cardiomyocyte proliferation, differentiation, survival, and reprogramming.
See this image and copyright information in PMC

Comment on

References

    1. Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu T-D, Guerquin-Kern J-L, Lechene CP, Lee RT. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013;493:433–436. - PMC - PubMed
    1. Eulalio A, Mano M, Ferro MD, Zentilin L, Sinagra G, Zacchigna S, Giacca M. Functional screening identifies miRNAs inducing cardiac regeneration. Nature. 2012;492:376–381. - PubMed
    1. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98–102. - PMC - PubMed
    1. Kajstura J, Urbanek K, Perl S, Hosoda T, Zheng H, Ogórek B, Ferreira-Martins J, Goichberg P, Rondon-Clavo C, Sanada F, D’Amario D, Rota M, del Monte F, Orlic D, Tisdale J, Leri A, Anversa P. Cardiomyogenesis in the Adult Human Heart
    1. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331:1078–1080. - PMC - PubMed

Publication types

LinkOut - more resources