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Editorial
. 2013 Jun 25;127(25):2472-4.
doi: 10.1161/CIRCULATIONAHA.113.003489. Epub 2013 May 23.

Sulfane sustains vascular health: insights into cystathionine γ-lyase function

Shyamal C Bir, Christopher G Kevil
Editorial

Sulfane sustains vascular health: insights into cystathionine γ-lyase function

Shyamal C Bir et al. Circulation. .
No abstract available

Keywords: Editorials; angiogenesis; atherosclerosis; inflammation; oxidative stress; preeclampsia/pregnancy.

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Conflict of interest statement

Conflicts of Interest Disclosures: None.

Figures

Figure 1
Figure 1
Role of CSE expression and H2S production in vascular dysfunction. Dysregulated CSE enzyme function through either pharmacologic inhibition or genetic deletion reduces H2S bioavailability. Reduced H2S production contributes to preeclampsia pathophysiology by increasing sFlt-1 and sEng levels and decreasing placental PIGF levels (right side pathway). Gene targeted knockout of CSE leads to decreased levels of GSH and SOD, increased levels of ROS and increased NF-κB mediated ICAM-1 expression that exacerbates atherosclerotic plaque formation (left side pathway). Abbreviations- CSE: Cystathionine γ-lyase, H2S: Hydrogen sulfide, sFlt-1: Soluble fms-like tyrosine kinase -1, sEng: Soluble endoglin, PIGF: Placental growth factor, NF-κB: Nuclear factor-kappaB, ICAM: intercellular adhesion molecule, GSH: Glutathione, SOD: Superoxide dismutase, ROS: Reactive oxygen species.
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