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Comment
. 2013 Jun;62(6):1816-7.
doi: 10.2337/db13-0261.

Treatment of hyaluronan accumulation ameliorates high-fat diet-induced insulin resistance in mice

Per Fogelstrand  1 , Jan Borén
Affiliations
Comment

Treatment of hyaluronan accumulation ameliorates high-fat diet-induced insulin resistance in mice

Per Fogelstrand et al. Diabetes. 2013 Jun.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Proposed model for how ECM remodeling is linked to high-fat diet–induced muscle insulin resistance. High-fat diet potentially leads to insulin resistance by several mechanisms, including inflammation that is closely linked to ECM expansion and remodeling. Interruptions of the pathway at several steps rescue insulin resistance. In the current study, Kang and colleagues (6) used hyaluronidase to degrade the HA in skeletal muscle. Earlier results from the same group have shown that overexpression of catalase in the mitochondria, which reduces oxygen free-radical production, prevented muscle inflammation, diminished ECM expansion, and rescued insulin resistance (5). Likewise, inhibition of phosphodiesterase 5A (PDE5a) has been shown to rescue insulin resistance by preventing ECM expansion (5).
See this image and copyright information in PMC

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