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Comment
. 2013 May 24;340(6135):924-d.
doi: 10.1126/science.1234089.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

Ashleigh R Price  1 , Guilian Xu, Zoe B Siemienski, Lisa A Smithson, David R Borchelt, Todd E Golde, Kevin M Felsenstein
Affiliations
Comment

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

Ashleigh R Price et al. Science. .

Abstract

Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrates short-term bexarotene treatment clearing preexisting β-amyloid deposits from the brains of APP/PS1ΔE9 mice with low amyloid burden, providing a rationale for repurposing this anticancer agent as an Alzheimer's disease (AD) therapeutic. Using a nearly identical treatment regimen, we were unable to detect any evidence of drug efficacy despite demonstration of target engagement.

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