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Comment
. 2013 May 24;340(6135):924-e.
doi: 10.1126/science.1233937.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

Ina Tesseur  1 , Adrian C Lo, Anouk Roberfroid, Sofie Dietvorst, Bianca Van Broeck, Marianne Borgers, Harrie Gijsen, Diederik Moechars, Marc Mercken, John Kemp, Rudi D'Hooge, Bart De Strooper
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Comment

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"

Ina Tesseur et al. Science. .

Abstract

Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid-lowering drug for Alzheimer's disease (AD). We were not able to reproduce the described effects in several animal models. Drug formulation appears very critical. Our data call for extreme caution when considering this compound for use in AD patients.

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