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Randomized Controlled Trial
. 2013 Jun;36(6):1772-4.
doi: 10.2337/dc12-2387.

Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial

TODAY Study Group
Collaborators
Randomized Controlled Trial

Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial

TODAY Study Group. Diabetes Care. 2013 Jun.

Abstract

Objective: To determine the prevalence of retinopathy in 517 youth with type 2 diabetes of 2-8 years duration enrolled in the TODAY study.

Research design and methods: Retinal photographs were graded centrally for retinopathy using established standards.

Results: Retinopathy was identified in 13.7% of subjects. Prevalence increased with age, diabetes duration, and mean HbA1c. Subjects in the highest BMI tertile had the lowest prevalence of retinopathy.

Conclusions: Prevalence of retinopathy and its association with HbA1c and diabetes duration is similar to that previously reported in youth with type 1 diabetes and in adults with type 2 diabetes of known duration. The mechanism underlying the reduced risk of retinopathy in the most obese individuals is unknown. Follow-up of this cohort will help define the natural history of retinopathy in youth with type 2 diabetes.

Trial registration: ClinicalTrials.gov NCT00081328.

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References

    1. Copeland KC, Zeitler P, Geffner M, et al. TODAY Study Group Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 2011;96:159–167 - PMC - PubMed
    1. Early Treatment Diabetic Retinopathy Study Research Group Grading diabetic retinopathy from stereoscopic color fundus photographs—an extension of the modified Airlie House classification (ETDRS report number 10). Ophthalmology 1991;98:S786–S806 - PubMed
    1. Zeitler P, Hirst K, Pyle L, et al. TODAY Study Group A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012;366:2247–2256 - PMC - PubMed
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