Polymicrogyria and congenital parvovirus b19 infection

Abstract

Fetal parvovirus B19 infection causes anemia, hydrops, and pregnancy loss but is generally not considered teratogenic. Nevertheless, disturbances of neuronal migration have been described with congenital parvovirus infection. We evaluated a term infant with congenital parvovirus disease and polymicrogyria. We compared this case with four other reports of central nervous system disease after birth to parvovirus-infected mothers. After an extensive diagnostic evaluation, this infant was found to have congenital parvovirus disease with severe anemia and nonimmune hydrops as well as extensive polymicrogyria. Although rare, this report and literature review suggest that parvovirus B19 has the potential to disrupt normal neurodevelopment. We suggest that infants with severe congenital parvovirus infection have close developmental surveillance and if symptomatic undergo neuroimaging to assess for disorders of neuromigration.

Keywords: Parvovirus; congenital infection; polymicrogyria; teratogen.

Figure 1

Patient brain magnetic resonance imaging (MRI). Axial (A) and coronal (B) T2-weighted postnatal MRI images of patient's brain demonstrating extensive polymicrogyria involving right frontal, temporal, and parietal lobes.