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. 2013 Jun 1;2(2):76-85.
doi: 10.1007/s13669-013-0040-0.

HPV-based Tests for Cervical Cancer Screening and Management of Cervical Disease

Patricia Luhn  1 , Nicolas Wentzensen
Affiliations

HPV-based Tests for Cervical Cancer Screening and Management of Cervical Disease

Patricia Luhn et al. Curr Obstet Gynecol Rep. .

Abstract

Current cervical cancer screening programs are changing due to the development of tests that detect the presence of human papillomavirus (HPV), the cause of cervical cancer. These tests are more sensitive than cytology-based methods for detecting cervical precancer and a negative test offers long-term assurance that cervical cancer will not develop and therefore longer screening intervals can be achieved. In screening programs, HPV-based tests have been approved to triage women with equivocal cytology results and as a primary testing method in conjunction with cytology. HPV-based tests also have a role in determining risk of recurrence after treatment for cervical precancer as well as in surveillance for vaccine-related changes in HPV genotype prevalence.

Keywords: HPV; cervical cancer; cervical precancer; management of HPV; prevention; screening; screening programs.

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Figures

Fig. 1
Fig. 1
The roles for HPV testing in cervical cancer prevention In the primary prevention of cervical cancer, HPV tests are used for monitoring vaccine efficacy and changes in genotype prevalence in vaccinated populations. In secondary prevention, HPV tests are used alone or in conjunction with cytology for screening. HPV tests are also used in determining who is referred to colposcopy by triaging equivocal cytology diagnoses or HPV positive women. Finally, HPV tests are important for evaluating risk of recurrence after treatment for cervical precancer.
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References

    1. Saslow D, Runowicz CD, Solomon D, Moscicki AB, Smith RA, Eyre HJ, et al. American Cancer Society guideline for the early detection of cervical neoplasia and cancer. CA Cancer J Clin. 2002;52:342–62. - PubMed
    1. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, et al. A review of human carcinogens--Part B: biological agents. Lancet Oncol. 2009;10:321–2. - PubMed
    1. Wentzensen N, Schiffman M, Dunn T, Zuna RE, Gold MA, Allen RA, et al. Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants. International Journal of Cancer. 2009;125:2151–58. - PMC - PubMed
    1. Rodriguez AC, Schiffman M, Herrero R, Wacholder S, Hildesheim A, Castle PE, et al. Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. J Natl Cancer Inst. 2008;100:513–7. - PMC - PubMed
    1. Plummer M, Schiffman M, Castle PE, Maucort-Boulch D, Wheeler CM. A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion. J Infect Dis. 2007;195:1582–9. - PubMed

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