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Review
. 2013 Aug 15;331(1-2):19-25.
doi: 10.1016/j.jns.2013.05.005. Epub 2013 May 21.

Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors

Kim Beerhorst  1 , Sylvie J M van der Kruijs, Pauline Verschuure, I Y Francis Tan, Albert P Aldenkamp
Affiliations
Review

Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors

Kim Beerhorst et al. J Neurol Sci. .

Abstract

An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.

Keywords: Anticonvulsant; Bone disease; Bone mineral density; Epilepsy; Fracture risk; Osteopenia; Osteoporosis; Rickets.

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