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Comment
. 2013 May 23;153(5):943-4.
doi: 10.1016/j.cell.2013.04.050.

Transitions for regulating early transcription

Margaux Michel  1 , Patrick Cramer
Affiliations
Free article
Comment

Transitions for regulating early transcription

Margaux Michel et al. Cell. .
Free article

Abstract

Gene expression is largely regulated during the initiation of RNA polymerase II (PolII) transcription. In this issue, Kouzine et al. show that control of DNA melting is one of the critical rate-limiting steps for productive mRNA elongation. We discuss these findings in the context of other key energetic transitions.

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  • Global regulation of promoter melting in naive lymphocytes.
    Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon KR, Bandle R, Nelson S, Nakahashi H, Awasthi P, Feigenbaum L, Menoni H, Hoeijmakers J, Vermeulen W, Ge H, Przytycka TM, Levens D, Casellas R. Kouzine F, et al. Cell. 2013 May 23;153(5):988-99. doi: 10.1016/j.cell.2013.04.033. Cell. 2013. PMID: 23706737 Free PMC article.

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