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Review
. 2013 Aug;16(4):479-84.
doi: 10.1016/j.mib.2013.04.006. Epub 2013 May 23.

Virome genomics: a tool for defining the human virome

Kristine M Wylie  1 , George M Weinstock, Gregory A Storch
Affiliations
Review

Virome genomics: a tool for defining the human virome

Kristine M Wylie et al. Curr Opin Microbiol. 2013 Aug.

Abstract

High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host that control infections, and evaluate gene expression of viruses and hosts during infection. Sequencing can also describe variation and evolution of viruses during replication and transmission. This review recounts some of the major advances in the studies of virus-host interactions from the last two years, and discusses the uses of sequencing technologies relating to these studies.

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Figures

Figure 1
Figure 1
The major topics of this review are summarized. Areas of virology research are noted in the blue boxes, and the text in the gray boxes describes how genomics can be used as a tool in that area of research.
See this image and copyright information in PMC

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