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. 2013 Jul:65:168-86.
doi: 10.1016/j.ejmech.2013.04.028. Epub 2013 Apr 24.

Sulphonamido-quinoxalines: search for anticancer agent

Rahul Ingle  1 , Rajendra Marathe, Dipak Magar, Harun M Patel, Sanjay J Surana
Affiliations

Sulphonamido-quinoxalines: search for anticancer agent

Rahul Ingle et al. Eur J Med Chem. 2013 Jul.

Abstract

A series of new sulphonamido-quinoxaline derivatives 3(a-p) have been prepared which are structurally similar to the High Throughput Screening (HTS) hit identified by Porter and collaborator. The newly synthesized compounds 3b, 3c, 3f, 3i, 3j, 3l, 3n and 3o were further evaluated in the National Cancer Institute for in vitro cytotoxicity assay among them compound 3l showed highest activity against Leukemia RPMI-8226 cell lines (GI50: 1.11 μM) as compared to other tested compounds. It is to be noted that compound 3l shows significant activity (GI50: 1.11 μM) compared to the High Throughput Screening (HTS) hit identified by Porter and collaborator (IC50 = 1.3 μM). Further docking study confirms the c-Met kinase inhibitory mechanism of the synthesized compounds.

Keywords: Anticancer; Docking; Lipinski's rule; Synthesis sulphonamido-quinoxaline.

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