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. 2013 Jul;16(7):845-7.
doi: 10.1038/nn.3401. Epub 2013 May 26.

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Grégory Conductier  1 , Frédéric Brau, Angèle Viola, Fanny Langlet, Navean Ramkumar, Bénédicte Dehouck, Thibault Lemaire, Raphaël Chapot, Laurianne Lucas, Carole Rovère, Priscilla Maitre, Salma Hosseiny, Agnès Petit-Paitel, Antoine Adamantidis, Bernard Lakaye, Pierre-Yves Risold, Vincent Prévot, Olivier Meste, Jean-Louis Nahon, Alice Guyon
Affiliations

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Grégory Conductier et al. Nat Neurosci. 2013 Jul.

Abstract

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

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References

    1. Mol Biol Cell. 2008 Apr;19(4):1540-7 - PubMed
    1. Histochem Cell Biol. 2008 Jul;130(1):71-7 - PubMed
    1. J Neurocytol. 1998 Nov;27(11):779-90 - PubMed
    1. J Neuroendocrinol. 2002 Mar;14(3):247-55 - PubMed
    1. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7024-9 - PubMed

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