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Comment
. 2013 Jun 1;12(11):1661-2.
doi: 10.4161/cc.25071. Epub 2013 May 17.

Rb and chromatin remodeling in the maintenance of the post-mitotic state of neurons

Alexandre Blais  1
Affiliations
Comment

Rb and chromatin remodeling in the maintenance of the post-mitotic state of neurons

Alexandre Blais. Cell Cycle. .
No abstract available

Keywords: E2F; LXCXE; Rb; cell cycle; chromatin structure; mitotic exit; neurons; retinoblastoma.

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Figures

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Figure 1. LXCXE-independent chromatin remodeling and cell cycle repression in mitotically arrested cells. Andrusiak et al. reported that in cortical neurons of the adult brain, which have permanently ceased proliferation, the acute loss of pRb leads to chromatin remodeling at cell cycle genes, to cell cycle re-entry and to apoptotic loss of neurons. In contrast, loss of pRb’s ability to interact with LXCXE-containing proteins does not lead to changes in chromatin structure or to cell cycle re-entry. Moreover, the loss of pRb phenotype can be reversed if the action of E2F proteins is blocked by the overexpression of a dominant-negative form of DP1 that blocks E2F DNA binding.
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References

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