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Comment
. 2013 Jun 1;12(11):1660-1.
doi: 10.4161/cc.25070. Epub 2013 May 17.

Progesterone and FOXO1 signaling: harnessing cellular senescence for the treatment of ovarian cancer

Jan J Brosens  1 , Eric W-F Lam
Affiliations
Comment

Progesterone and FOXO1 signaling: harnessing cellular senescence for the treatment of ovarian cancer

Jan J Brosens et al. Cell Cycle. .
No abstract available

Keywords: FOXO1; PI3K; cancer; cell cycle; decidua; endometrium; ovary; progesterone; progesterone receptor; progestin; senescence.

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Figures

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Figure 1. Progestin-dependent activation of the senescence pathway. Cancer cells have increased capacity to proliferate. Cellular senescence can be triggered by various insults. Progesterone promote ovarian cancer cells to enter senescence through activation of the progesterone receptor (PR), which cooperates with FOXO1 to induce expression of senescence-associated cell cycle inhibitors, including FOXO1, p15INK4b, p16INK4a, p21Cip1 and p27Kip1.
See this image and copyright information in PMC

Comment on

References

    1. Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer. 2010;10:51–7. doi: 10.1038/nrc2772. - DOI - PMC - PubMed
    1. Diep CH, Charles NJ, Gilks CB, Kalloger SE, Argenta PA, Lange CA. Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle. 2013;12:1433–49. doi: 10.4161/cc.24550. - DOI - PMC - PubMed
    1. Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J, et al. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem. 2000;275:21960–8. doi: 10.1074/jbc.M000759200. - DOI - PubMed
    1. Modugno F, Laskey R, Smith AL, Andersen CL, Haluska P, Oesterreich S. Hormone response in ovarian cancer: time to reconsider as a clinical target? Endocr Relat Cancer. 2012;19:R255–79. doi: 10.1530/ERC-12-0175. - DOI - PMC - PubMed
    1. Gellersen B, Fernandes MS, Brosens JJ. Non-genomic progesterone actions in female reproduction. Hum Reprod Update. 2009;15:119–38. doi: 10.1093/humupd/dmn044. - DOI - PubMed

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