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Meta-Analysis
. 2013 Jul;15(4):497-502.
doi: 10.1038/aja.2012.174. Epub 2013 May 27.

Efficacy and safety of local anaesthetics for premature ejaculation: a systematic review and meta-analysis

Jia-Dong Xia  1 , You-Feng Han, Liu-Hua Zhou, Yun Chen, Yu-Tian Dai
Affiliations
Meta-Analysis

Efficacy and safety of local anaesthetics for premature ejaculation: a systematic review and meta-analysis

Jia-Dong Xia et al. Asian J Androl. 2013 Jul.

Abstract

To assess the efficacy and safety of local anaesthetics for premature ejaculation (PE), a systematic review of the literature was performed using the Cochrane Library, PUBMED and EMBASE. We screened and retrieved the randomized controlled trials on the treatment of PE with local anaesthetics. End points included intravaginal ejaculation latency time (IELT), patient-reported outcome assessments and adverse events. Meta-analyses were conducted with Stata 11.0. In total, seven publications involving 566 patients with local anaesthetics and 388 with placebos strictly met our eligibility criteria. Meta-analyses showed that after the patients were treated with the local anaesthetics, the value of the standardized mean difference of the changes in IELT was 5.02 (95% CI: 3.03-7.00). A higher rate of adverse events occurred compared with placebos (odds ratio: 3.30, 95% CI: 1.71-6.36), but these events were restricted to local side effects. In addition, significantly greater improvement was observed in patient-reported outcomes. In summary, local anaesthetics can prolong IELT and improve ejaculatory control and sexual satisfaction.

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Figures

Figure 1
Figure 1
Flow diagram of the studies identified in the meta-analysis.
Figure 2
Figure 2
Pooled estimates of the IELT of local anaesthetics vs. placebo. Each subgroup analysis is presented separately. Weights are from random effects analysis. EMLA, eutectic mixture of local anaesthetics; IELT, intravaginal ejaculation latency time; SMD, standardized mean difference; TEMPE, topical eutectic mixture for premature ejaculation.
Figure 3
Figure 3
The sensitivity analysis diagram for each study used to calculate the efficacy of the local anaesthetics in the treatment of PE. The given named-study is omitted.
Figure 4
Figure 4
Pooled estimates of side effects of the local anaesthetics vs. placebo.
See this image and copyright information in PMC

References

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