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. 2013 Aug;94(2):211-3.
doi: 10.1038/clpt.2013.111. Epub 2013 May 24.

Challenges in the pharmacogenomic annotation of whole genomes

R B Altman  1 , M Whirl-Carrillo, T E Klein
Affiliations

Challenges in the pharmacogenomic annotation of whole genomes

R B Altman et al. Clin Pharmacol Ther. 2013 Aug.

Abstract

Next-generation sequencing technologies have enabled the sequencing of an entire genome for less than $4,000. With access to all the genetic variation in an individual, our task will be to use this information to assess the genetic influences on drug efficacy, toxicity, and dosage.

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Conflict of interest statement

CONFLICT OF INTEREST

R.B.A. is a founder of and consultant to Personalis, which focuses on clinical genomics using next-generation sequencing. The other authors declared no conflict of interest.

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