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Review
. 2013 Jun;44(6 Suppl 1):S23-5.
doi: 10.1161/STROKEAHA.112.679357.

Whole genome expression of cellular response to stroke

Frank R Sharp  1 , Glen C Jickling
Affiliations
Review

Whole genome expression of cellular response to stroke

Frank R Sharp et al. Stroke. 2013 Jun.
No abstract available

Keywords: arrays; cryptogenic; gene expression; leukocytes; stroke.

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Conflict of interest statement

Conflicts of Interest/ Disclosures. The authors have no conflicts of interest or disclosures to report.

Figures

Figure 1
Figure 1
Schematic of interactions between circulating leukocytes and factors involved in ischemic stroke, including blood clots, platelets, atherosclerotic plaque and damaged endothelial cells. Each factor can influence expression of leukocyte RNA. This figure is reproduced from an article published in Journal of Cerebral Blood Flow and Metabolism by Sharp et al.
Figure 2
Figure 2
Algorithm for predicting causes of cryptogenic strokes using gene expression profiles from circulating leukocytes. MRI is used to classify a stroke as a Small Deep Infarct (SDI) or non-SDI infarct (cortical, cerebellar, etc). A 41 gene profile is used to distinguish lacunar and non-lacunar SDI. A 40 gene profile is then used to distinguish cardioembolic and large vessel arterial causes of non-SDI causes of stroke. Approximately 58% of cryptogenic strokes are predicted to be cardioembolic. This Figure is reproduced from an article published in Stroke by Jickling et al.
See this image and copyright information in PMC

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References

    1. Whiteley W, Chong WL, Sengupta A, Sandercock P. Blood markers for the prognosis of ischemic stroke: A systematic review. Stroke. 2009;40:e380–e389. - PubMed
    1. Montaner J. Blood biomarkers to guide stroke thrombolysis. Front Biosci. 2009;1:200–208. - PubMed
    1. Jensen MB, Chacon MR, Sattin JA, Levine RL, Vemuganti R. Potential biomarkers for the diagnosis of stroke. Expert Rev Cardiovasc Ther. 2009;7:389–393. - PubMed
    1. Jickling GC, Sharp FR. Blood biomarkers of ischemic stroke. Neurotherapeutics. 2011;8:349–360. - PMC - PubMed
    1. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Liu D, et al. Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans. J Cereb Blood Flow Metab. 2011;31:1513–1531. - PMC - PubMed

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