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. 2013 Aug 1;442(2):97-100.
doi: 10.1016/j.virol.2013.04.014. Epub 2013 May 25.

Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012

C G Albariño  1 , T Shoemaker, M L Khristova, J F Wamala, J J Muyembe, S Balinandi, A Tumusiime, S Campbell, D Cannon, A Gibbons, E Bergeron, B Bird, K Dodd, C Spiropoulou, B R Erickson, L Guerrero, B Knust, S T Nichol, P E Rollin, U Ströher
Affiliations

Genomic analysis of filoviruses associated with four viral hemorrhagic fever outbreaks in Uganda and the Democratic Republic of the Congo in 2012

C G Albariño et al. Virology. .

Abstract

In 2012, an unprecedented number of four distinct, partially overlapping filovirus-associated viral hemorrhagic fever outbreaks were detected in equatorial Africa. Analysis of complete virus genome sequences confirmed the reemergence of Sudan virus and Marburg virus in Uganda, and the first emergence of Bundibugyo virus in the Democratic Republic of the Congo.

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Figures

Fig. 1
Fig. 1
Map of the Democratic Republic of the Congo (DRC) and Uganda showing the locations of filovirus-caused viral hemorrhagic fever (VHF) outbreaks in 2012. Isolation sites of the most genetically similar viruses from previous years are also shown.
Fig. 2
Fig. 2
Phylogenetic trees comparing representative full-length genomes of ebolavirus (A) and marburgvirus (B). Evolutionary analyses were conducted in MEGA5 (Tamura et al., 2011), using the neighbor-joining method. Bootstrap values listed at the nodes provide statistical support for 500 replicates. Scale bar indicates the number of substitutions per site. Genomes from 2012 are in red; † indicates fatal cases. Genbank accession numbers used in A are: FJ968794, EU338380, NC_014373, FJ217162, NC_004161, JN638998, NC_006432, AF086833, AY354458, and KC242783. SUDV sequences from 2012 outbreaks are: KC545389, KC545390, KC545391, KC545392 and KC589025. BDBV sequences from 2012 outbreaks are: KC545393, KC545394, KC545395, and KC545396. Genbank accession numbers used in B are: DQ447654, JX458858, FJ750958, JX458853, JN408064, FJ750957, DQ447649, DQ217792, DQ447658, DQ447650, DQ447651, and FJ750953. MARV sequences from 2012 outbreaks are: KC545387 and KC545388.
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